Polygonum shastense is a species of flowering plant in the knotweed family known by the common name Shasta knotweed. It is native to sections of southwestern Oregon, northwestern Nevada, and northern and central California, where it grows in rocky and gravelly mountainous habitat up to 3300 meters (11,000 feet) elevation. It is most common in the Sierra Nevada. The species name refers to its occurrence on Mount Shasta in Shasta County, California.

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