Polypedates iskandari is a species of frogs in the family Rhacophoridae. It is endemic to Sulawesi, Indonesia. It belongs to the Polypedates leucomystax species complex; it was split from Polypedates leucomystax in 2011 based on a morphometric analysis. This split has been challenged because male vocalizations between specimens from Sulawesi and Java show only minor differences and because genetic differences (as shown by Brown and colleagues) are low.

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