Polysphaeria is a genus of plants in the family Rubiaceae, and its native range is Madagascar and Tropical Africa. It contains the following 22 species according to Plants of the World Online:

• Polysphaeria acuminata Verdc.
• Polysphaeria aethiopica Verdc.
• Polysphaeria arbuscula K.Schum.
• Polysphaeria braunii K.Krause
• Polysphaeria capuronii Verdc.
• Polysphaeria cleistocalyx Verdc.
• Polysphaeria dischistocalyx Brenan
• Polysphaeria grandiflora Cavaco
• Polysphaeria grandis (Baill.) Cavaco
• Polysphaeria hirta Verdc.
• Polysphaeria lanceolata Hiern
• Polysphaeria lepidocarpa Verdc.
• Polysphaeria macrantha Brenan
• Polysphaeria macrophylla K.Schum.
• Polysphaeria maxima (Baill.) Cavaco
• Polysphaeria multiflora Hiern
• Polysphaeria ntemii S.E.Dawson & Gereau
• Polysphaeria ovata Cavaco
• Polysphaeria parvifolia Hiern
• Polysphaeria pedunculata K.Schum. ex De Wild.
• Polysphaeria subnudifaux Verdc.
• Polysphaeria tubulosa (Baill.) Cavaco

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