Prestonia is a genus of plants in the dogbane family Apocynaceae. First described as a genus in 1810, it currently includes 63 species of lianas. They are native to Mexico, Central America, South America, and the West Indies. Their flowers are tube or funnel shaped and have 5 petals, often with noticeable annular coronas. Prestonia amazonica, which is often named as a hallucinogenic plant, belongs to this genus.

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