Pyxidanthera brevifolia, the littleleaf pixiemoss or sandhills pyxie-moss, is a plant species known only from North Carolina and South Carolina. It occurs in deep, sandy soil such as sand hills and sandy ridgetops, sometimes in open pine-oak woodlands, at elevations of 50–200 m (160–660 ft).

Pyxidanthera brevifolia is closely related to the more widespread P. barbulata, and some authors have suggested considering the two as a single species. For the moment, though, Flora of North America and the Kew Gardens Plant List both accept P. brevifolia as a distinct species. The two can be distinguished by the leaves. Leaves of P. brevifolia are shorter than those of P. barbulata, rarely more than 4 millimetres (0.16 in) long. They also lack the marginal cilia characteristic of P. barbulata, and are more intensely woolly on the underside.

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