Pyxis is a constellation in the Southern Hemisphere.

Pyxis may also refer to:

• Pyxis (vessel), a piece of ancient Greek pottery
• Pyxis (turtle), a turtle genus
• Pyxis, a type of capsular fruit where the upper part falls off
• Pyxis, a Japanese idol duo consists of Miku Itō and Moe Toyota
• Pyxis Corporation, a manufacturer of medical technologies and automated dispensing cabinet (ADC) for medications
• Sony Pyxis, an early GPS navigation device launched in 1991

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