Semele is the mother of Dionysus in Greek mythology.

Semele may also refer to:

• Semele (play), a lost tragedy by Aeschylus
• Semele (Eccles), an opera by John Eccles
• Semele (Handel), an opera by George Frideric Handel (given as an oratorio in its first run)
• Semele (Schiller), a singspiel libretto by Friedrich Schiller
• Sémélé, an opera by Marin Marais
• Sémélé (Dukas cantata), a cantata by Paul Dukas
• 86 Semele, an asteroid
• Semele (plant), a genus of flowering plants
• Semele (bivalve), a genus of bivalves
• Radford Semele, a village in Warwickshire, England

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