Spermacoce glabra, smooth false buttonweed, is a New World species of plants in the coffee family.

The species is widespread across much of North America and South America. In the United States, it is found in the southern part of the Mississippi Valley from Illinois to Louisiana, the range extending westward into Texas, Oklahoma and eastern Kansas, and eastward along the Ohio River. Isolated populations are reported from further east, in Maryland, Virginia, South Carolina, Georgia and Florida. The species also occurs in southern Mexico (Tabasco and Campeche), Honduras, and South America (Colombia, Venezuela, Ecuador, Brazil, Paraguay, Uruguay and Argentina).

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