Thrixopelma pruriens, known as the Peruvian green velvet tarantula, is a species of tarantula found in Chile and Peru in South America.

Though docile, this species is rarely kept as a pet in part due to its tendency to fling urticating hairs with minimal provocation.

In 2014, researchers at Yale University identified a toxin called Protoxin-I from the tarantula's venom that shows promise as a new painkiller drug. The toxin reduces activity in an ion channel associated with inflammation and neuropathic pain, making it potentially suitable as a treatment for both normal pain and pathological pain syndromes.

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