Tlepolemus is a Greek mythological figure, a son of Heracles who fought on the Greek side in the Trojan War.

Tlepolemus may also refer to:

• Tlepolemus (beetle), a genus of beetles
• Tlepolemus (general), one of the generals of Alexander the Great in 336-323 BC
• Tlepolemus (regent of Egypt), regent in Ptolemaic Egypt around 200 BC
• Tlepolemus Cornelius, Roman painter of the 1st century BCE, and agent of Gaius Verres

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