Trillium grandiflorum, the white trillium, large-flowered trillium, great white trillium, white wake-robin or French: trille blanc, is a species of flowering plant in the family Melanthiaceae. A monocotyledonous, herbaceous perennial, the plant is native to eastern North America, from northern Quebec to the southern parts of the United States through the Appalachian Mountains into northernmost Georgia and west to Minnesota. There are also several isolated populations in Nova Scotia, Maine, southern Illinois, and Iowa.

Trillium grandiflorum is most common in rich, mixed upland forests. It is easily recognized by its attractive three-petalled white flowers, opening from late spring to early summer, that rise above a whorl of three leaf-like bracts. It is an example of a spring ephemeral, a plant whose life-cycle is synchronized with that of the deciduous woodland which it favours.

White trillium often occurs in dense drifts of many individuals. The G. Richard Thompson Wildlife Management Area in the Blue Ridge Mountains is renowned for an extensive stand of white trillium that blooms each spring. Over a two square mile area along the Appalachian Trail near Linden, Virginia there is a spectacular annual display of white trilliums estimated at near ten million individuals.

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