Trypoxylon is a genus of wasps in the family Crabronidae. All Trypoxylon species that have been studied so far are active hunters of spiders, which they paralyse with a venomous sting, to provide as food to their developing larvae. Depending on the species, they will either construct their own nest from mud or find cavities that already exist. These cavities can range from keyholes to nail holes to previously abandoned nests, and are generally sealed with mud to create cells for their larvae.

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