Uroplatus sameiti is a species of leaf-tailed gecko. Like all members of the genus Uroplatus, U. sameiti is endemic to Madagascar, and is found in primary and secondary forests on the island. It has the ability to change its skin colour to match its surroundings and possesses dermal flaps which break up its outline when at rest.

It is a CITES II protected animal due to habitat loss and over-collection for the pet trade.

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