Side-blotched lizards are lizards of the genus Uta. They are some of the most abundant and commonly observed lizards in the deserts of western North America, known for cycling between three colorized breeding patterns and best described by the common side-blotched lizard. They commonly grow to 6 inches including the tail, with the males normally being the larger sex. Males often have bright throat colors.

These lizards are prey for many desert species. Snakes, larger lizards, and birds all make formidable predators to side-blotched lizards. Larger lizard species, such as collared, leopard, and spiny lizards, and roadrunners are the main predators. In turn, the side-blotched lizards eat arthropods, such as insects, spiders, and occasionally scorpions.

As a result of their high predation rate, these lizards are very prolific breeders. From April to June, they breed, with the young emerging as early as late May. These inch-long young appear all through the summer, and into September.

The diploid chromosome number in most if not all species is 34, consisting of 12 macro- and 22 microchromosomes.

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