Wyethia arizonica, the Arizona mule's ears, is a plant species native to Arizona, Colorado, New Mexico and Utah. It grows in meadows in coniferous forests at elevations of 600–3,000 m (2,000–9,800 ft).

Wyethia arizonica is a perennial herb with a large taproot, the shoot up to 100 cm (39 in) tall. Leaves are elliptic to lanceolate, up to 30 cm (12 in) long. Flower heads are 1-4 per plant, with yellow flowers.

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