Agave murpheyi is a species of agave. It is a succulent plant that is found growing only at a few dozen archaeological sites of the ancient Hohokam Indians in southern Arizona and northern Sonora, Mexico. In 1935, there were reported half a dozen sites and in 1970 only two were known. It appears to be a cultivar grown by the Hohokam for food and fiber. Its common names include Hohokam agave, Murphey agave, and Murphey's century plant.

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