Hypericum grandifolium, the large-leaved St John's wort, is a species of flowering plant in the family Hypericaceae. The plant is a bushy shrub that can grow to almost 2 meters tall. It has large leaves, golden yellow petals, and seed capsules that split open. H. grandifolium is native to the Canary Islands and Madeira in Macaronesia, but has become invasive in other regions, including California, after escaping from cultivation as an ornamental plant. It is parasitized by wasps and fungi, and is capable of reproducing through its rhizomes.

First described in 1821 by Jacques Choisy, the ambiguity of its original description meant that the species was often misidentified. Specimens were variously called H. elatum, H. anglicum, Androsaemum webbianum, and others. The species was placed into section Androsaemum of Hypericum by Norman Robson in 1984, and it is most closely related in appearance and classification to the other species in the section, especially H. androsaemum, H. hircinum, and H. × inodorum. The species is not used in modern medical applications, but may have anticancer potential and could be used to treat ear edemas.

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