Hypericum punctatum, the spotted St. John's wort, is a perennial herb native to North America. The yellow-flowered herb occurs throughout eastern North America into southern Canada. The process of microsporogenesis carried out by this plant is prone to errors in chromosomal segregation. It has a diploid number of 14 or 16. Insects are attracted to the plant's pollen and the hypericin in the plant's leaves is toxic to mammals.

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