Leptodactylus fragilis, known under many common names such as the Mexican white-lipped frog, American white-lipped frog or simply white-lipped frog, is a species of leptodactylid frog. Its distribution ranges from the Lower Rio Grande Valley of Texas in the United States south through Mexico and Central America to Colombia and Venezuela. It is often—wrongly—referred to as Leptodactylus labialis (Cope, 1878) (or Leptodactylus mystaceus labialis Shreve, 1957), which is a junior synonym of Leptodactylus mystacinus.

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