Lycium fremontii is a species of flowering plant in the nightshade family, Solanaceae, that is native to northwestern Mexico and the southernmost mountains and deserts of California and Arizona in the United States. It often grows in areas with alkaline soils, such as alkali flats.

Both its common name, Frémont's desert thorn, and its specific epithet, "fremontii", are derived from John C. Frémont.

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