Mollisiaceae is a family of fungi in the order Helotiales. It contains almost 800 species in 17 genera with multiple genera remaining undescribed. Saprotrophs and root endophytes are prominent in the family but it also includes endophytes of other plant tissues. Due to a lack of accessible morphological features, the family has been difficult to study resulting in limited understanding of its taxonomy. Genetic studies suggest that the family comprises much overlooked biodiversity.

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