Mylossoma is a genus of serrasalmids from tropical and subtropical South America, including the basins of the Amazon, Orinoco, Lake Maracaibo and Paraguay-Paraná. These common fish are found both in main river sections and floodplains. They support important fisheries and based on a review by IBAMA, they are the seventh most caught fish by weight in the Brazilian Amazon. They primarily feed on plant material such as seeds and fruits (to a lesser extent invertebrates), and in their ecology they generally resemble the larger tambaqui (Colossoma macropomum). Mylossoma reach up to 28.5 cm (11.2 in) in length and 1 kg (2.2 lb) in weight.

Fossil remains are known from the Middle Miocene-aged Pebas Formation of Peru.

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