Vitis rotundifolia, or muscadine, is a grapevine species native to the southeastern and south-central United States. The growth range extends from Florida to New Jersey coast, and west to eastern Texas and Oklahoma. It has been extensively cultivated since the 16th century. The plants are well-adapted to their native warm and humid climate; they need fewer chilling hours than better known varieties, and thrive in summer heat.

Muscadine berries may be bronze or dark purple or black when ripe. Wild varieties may stay green through maturity. Muscadines are typically used in making artisan wines, juice, hull pie and jelly. They are rich sources of polyphenols.

In a natural setting, muscadine provides wildlife habitat as shelter, browse, and food for many birds and animals. It is also a larval host for the Nessus Sphinx Moth (Amphion floridensis) and the Mournful Sphinx Moth (Enyo lugubris).

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