Salvia melaleuca is a perennial undershrub that is endemic to the north central region of the Eastern Cordillera in Colombia. It is a close relative of S. rubescens, with a villous and much larger corolla than that species. Salvia melaleuca grows approximately 0.5 to 2.5 m (1.6 to 8.2 ft) high, has a red corolla that is 3.5 to 4.5 cm (1.4 to 1.8 in) long, with the upper lip typically 9 mm (0.35 in) long but sometimes up to 15 mm (0.59 in).

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