Pristimantis factiosus is a species of frog in the family Strabomantidae. It is endemic to the eastern slopes of the Cordillera Central in Colombia and only known from near its type locality, El Estadero in Samaná, Caldas Department, and from Anorí, Antioquia Department. The IUCN SSC Amphibian Specialist Group, however, has mapped its distribution as continuous between these locations. The specific name factiosus refers to sexual dimorphism in coloration of the flanks.

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