Pristimantis tribulosus is a species of frog in the family Strabomantidae. It is endemic to Colombia and is only known from the vicinity of its type locality near Samaná in the Caldas Department, on the eastern slope of the Cordillera Central (Colombian Andes). The specific name tribulosus, meaning "thorny", refers to the numerous tubercles that cover the upper surfaces of this species.

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