Synodontis greshoffi is a species of upside-down catfish native to the Congo Basin of Cameroon, the Democratic Republic of the Congo and the Republic of the Congo. It was first collected by M.A. Greshoff in Pool Malebo on the upper Congo River, and the species was named for him by the author of the first paper written about the species, Belgian ichthyologist Louise Schilthuis, in 1891.

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