Synodontis polystigma is a species of upside-down catfish that is native to the upper Congo Basin of the Democratic Republic of the Congo and Zambia. It was first described by George Albert Boulenger in 1915. The original specimens were obtained at Lukonzolwa, in Lake Mweru, in what is now the Democratic Republic of the Congo. The species name polystigma is derived from poly, meaning "many" and stigma, meaning "mark or spot", referring to the numerous black spots on the body and fins of the species.

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